Folinic Acid

Bio-Activity Analysis
Bioavailability Comparison
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Immediate Energy Boost: It helps convert food into fuel more efficiently.
- Brain Health: Essential for producing neurotransmitters like serotonin and dopamine.
- Cellular Repair: Crucial for making and repairing DNA.
- Detoxification: Helps your body process and eliminate toxins.
Deep Dive
Folinic Acid is a powerhouse for your metabolism. It works alongside Vitamin B12 to create methionine, an amino acid critical for heart health and liver function. Because it bypasses the rate-limiting enzyme in the folate cycle (MTHFR), it is often recommended for individuals with MTHFR gene mutations who struggle to process standard supplements. It is also widely used to mitigate the side effects of certain medications (like Methotrexate) by helping healthy cells recover. It supports the nervous system, promotes healthy red blood cell formation, and ensures your cells are dividing correctly.
Natural Food Sources
While synthetic folate is common in processed foods, natural folate is found in whole foods. Folinic acid is chemically similar to the folate naturally found in these foods.
| Food | Amount | % DV |
|---|---|---|
| Beef Liver | 1 cup | 600% |
| Spinach (Cooked) | 1 cup | 66% |
| Asparagus | 1 cup | 65% |
| Brussels Sprouts | 1 cup | 47% |
| Avocado | 1 whole | 30% |
Supplementation
Dietary folate is generally safe. However, for supplements:
- Typical Dosage: 400–800 mcg daily is common for general health. Higher doses are used therapeutically under medical guidance.
- Who Should Take It? People with MTHFR mutations, those taking methotrexate, or individuals seeking a more bioavailable form of folate than standard folic acid.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Folinic Acid is generally well-tolerated. However, because it is a potent chemical that encourages cell growth, caution is needed.
Who should avoid or be careful?
- Cancer Patients: Because it supports cell growth, it may theoretically interfere with certain chemotherapy drugs (though it is often used to protect healthy cells during treatment—consult your oncologist).
- Vitamin B12 Deficiency: Taking folate can mask a B12 deficiency, potentially allowing nerve damage to progress unnoticed. Always take with B12.
- Seizure Medications: May interact with drugs like phenytoin.
Side Effects: Rare, but may include nausea, loss of appetite, or irritability.
Scientific References
- [1]MTHFR.net: Clinical data on Leucovorin (Folinic Acid) efficacy.
- [2]National Institutes of Health (NIH) - Office of Dietary Supplements: Folate Fact Sheet.
- [3]Journal of Inherited Metabolic Disease: The role of folinic acid in cerebral folate deficiency.