Nicotinamide

Bio-Activity Analysis
NAD+ Precursor Bioavailability
SCIENTIFIC DATA VISUALIZATION
Health Benefits & Sources
Why You Need It
- Boosts Cellular Energy: It is a precursor to NAD+, a vital molecule that fuels your mitochondria (the power plants of your cells).
- Supports Healthy Skin: It strengthens the skin barrier, helps retain moisture, and can calm redness and irritation.
- Protects Cellular DNA: It aids in repairing damaged DNA, which is a crucial defense against aging and environmental stressors.
Deep Dive
Nicotinamide functions primarily by participating in the creation of NAD+ (Nicotinamide Adenine Dinucleotide). As we age, our NAD+ levels naturally drop, leading to lower energy and slower cellular repair. By supplementing with Nicotinamide, you help replenish these levels, essentially giving your cells the fuel they need to repair themselves and produce energy efficiently. Topically and internally, it inhibits the transfer of pigment within the skin, which can help reduce the appearance of dark spots and uneven skin tone.
Natural Food Sources
Getting Vitamin B3 from food is the most effective way to ensure you get a balance of other nutrients. It is water-soluble, meaning your body doesn't store it for long, so regular intake is key.
| Food | Amount | % DV (Daily Value) |
|---|---|---|
| Chicken Breast (Cooked) | 11.8 mg | 74% |
| Tuna (Yellowfin) | 8.5 mg | 53% |
| Turkey Breast | 6.3 mg | 39% |
| Peanuts (Roasted) | 4.2 mg | 26% |
| Lentils (Boiled) | 2.1 mg | 13% |
Supplementation
While food is best, supplements are useful for specific goals (like skin health or energy support). Nicotinamide is often found in skin serums (topical) or oral capsules. Unlike Niacin, Nicotinamide does not usually cause the 'niacin flush' (itchy, red skin), making it a gentler option for oral supplementation.
Top Food Sources
Frequently Asked Questions
Safety & Side Effects
Nicotinamide is generally recognized as safe and well-tolerated at recommended doses.
Who should avoid it?
- Individuals with liver disease should consult a doctor before taking high doses (above 1000mg/day), as it can be hard on the liver.
- People with diabetes should monitor blood sugar closely, as it may lower blood sugar levels.
Side Effects: Side effects are rare at standard doses (under 500mg/day). High doses may cause mild nausea, itching, or headaches. It may interact with certain antibiotics (like tetracyclines) and blood pressure medications.
Scientific References
- [1]Bogan, K. L., & Brenner, C. (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular view of vitamin B3 nutrition in humans. *Annual Review of Nutrition*.
- [2]Bissett, D. L., et al. (2010). The effects of niacinamide on the cutaneous aging process. *Journal of Cosmetic Dermatology*.
- [3]Knip, M., et al. (2005). Safety of high-dose nicotinamide in the treatment of new-onset type 1 diabetes. *Diabetic Medicine*.